|DATE||Friday March 03,|
|AUTHOR||Dr. Carlos Orozco (BSc, MSc, ND, MD, PhD, FPAMS)|
Epigenetic information allows for communication through vibration and resonance
Communication is a signaling system generated in the realm of epigenetics that allows for the interchange of energy into matter and vice versa via bio-photons1,2. This important information is not reflected by DNA itself. Its impact on our wellbeing occurs in what has been labeled epigenetics, which accounts for up to 98%of the non-nuclear-coding DNA otherwise known as junk DNA where the micro cellular environment, that is independent of the DNA, receives environmental signals i.e. information, through proteins called histones and chromatin3. Genetic determination (DNA) and gene expression are driven by 2% of the human genome. The DNA is packed into pockets of information called genes. Every gene has a specific place within the autosomes and chromosomes called locus for one gene, loci for several genes. So, we can safely say that our genes 26 do not control our Biology, it is all about the environmental signals that affect the body’s epigenetics4 via non-coding DNA.
Epigenetics is the study of gene expression under the influence of informational signals emanating from the micro and the macro environment, where the phenotype changes and the genotype remain the same due to methylations of the histones and chromatin.
Back in 2000, The Human Genome project was completed and it was finalized in 2003 and shared with scientists throughout the world. The revelations and discoveries highlighted that only 25,000 genes made up the entire human genome; even though the scientists involved expected that the numbers would be in the hundreds of thousands. The discoveries pondered the question: ‘Why do humans’ have over 100,000 structural and globular proteins making up the human body and yet there are only 25,000 genes in code for them?’ The only answer was that something else was in control of the phenotypes and not just the genome – epigenetics.
The theory of modern day epigenetics was proposed by American biologist Prof. C David Allis. Epigenetics works by means of expressing the phenotype without the interference of the genotype. The biochemical mechanisms’ that have been elucidated to explain how non-coding DNA is able to express and silence genes are:
1. RNAi – siRNA’s silence gene expression in a sequence-specific manner by hybridizing to complementary regions within mRNAs.
2. Chromatin Remodeling– Acetylation and deacetylation of histones is the simplest type of chromatin remodeling.
3. DNA Methylation– Biological process binding methyl groups to the gene’s promoter region. Recognized as the prominent epigenetic mechanism involved in silencing gene expression.l
Epigenetics, as the science is named, was first postulated as ‘Lamarckism’ by Jaen-Baptiste Lamarck (1744-1829) who was an early evolutionist. He proposed that life forms could acquire ‘information’ from their environment and pass it on in their genes. Years later Erwin Schrödinger (1887-1961) applied the theoretical model of quantum physics into the field of molecular biology and set the basis for what we now know as epigenetics. Erwin Schrödinger believed that there existed a kind of a ‘code-script’ in the gene, as well as the persistence of genetic hereditary characters. At the time DNA was thought of as thought of as information somehow encodes the protein, that gave it the ability to self-organize. This interdisciplinary innovation opened a new door to molecular biology and directly triggered the discovery of DNA double helix structure afterward. At this point, it was believed that Schrödinger was referring to the ability of genes to produce specific proteins, when it is more likely he was referring to the organization of these proteins into biological complexity through external influences, bringing Lamarckism into the equation. Biology was then thought to be unable, to be further studied in the microcosmic world, under a microscope. Erwin Schrödinger imagined the tiniest structure of an organism to be an atom and commenced the theoretical physics and ideas of quantum mechanics and quantum fields.
After Erwin Schrödinger, the Research Director Prof.Rupert Sheldrake who worked at the Biochemistry and Cytobiology Lab of Clare College at the University of Cambridge developed and proposed the Sheldrake Theory Sheldrake’s “Morphic Resonance Hypothesis”. He proposed Morphic fields and resonance as the organizing fields of nature and matter. The Morphic fields interact with each other 18
through the process of what we can call Morphic Resonance. Fields are invisible structures in space, Michael Faraday proposed in the 1840’s that fields were made of subtle matter such as the Ether.
In the mid-1860’s James Maxwell, showed that light was electromagnetic vibration in the electromagnetic field. This became the basis of electrical technology. In 1905 Albert Einstein as he developed his theory of relativity, he got rid of the concept of the ether and said that fields are just fields. They are made of energy and thus they are fundamental in nature. M atter is made of fields but fields are not made of matter. In 1927 Einstein showed through his theory of relativity that the universal gravitational field is a field that holds the entire universe together.
In quantum theory, we now talk about Quantum Fields such as the quantum energy field and the biological information field.In recent times, leading stem cell biologist and expert on epigenetics, DrBruce Lipton, has taken a scientific understanding of the role of the environment (micro and macro) in gene expression to new levels. He produced breakthrough studies on the cell membrane, which revealed that this outer layer of the cell was an organic homolog of a computer chip, the cell’s equivalent of a brain. His research at Stanford University’s School of Medicine, between 1987 and 1992, revealed that the environment, operating though the membrane, controlled the behavior and physiology of the cell, turning genes on and off. His discoveries, which ran counter to the established scientific view that life is controlled by the genes, was the forerunner of one of today’s most important fields of study, the science of epigenetics.
Epigenetics is the study of the changes in the gene expression that are not due to an alteration of the DNA sequence which is heritable. It was Conrad Hal Waddington who coined the term Epigenetics for the first time in 1942. Epigenetics (from the Greek “epi” in or on, and “Genetics” the study of the genotype and phenotype characteristics that are transmitted from generation to generation through information packages called genes) plays a very important role in modern genetics, as it considers the genetic expression based on the signals that the epigenome receives from the environment and lifestyle of the individual. These genetic factors are determined by the cellular environment rather than by heritage. They intervene in the setting of the ontogeny or development of an organism, from the fertilization of the zygote in sexual reproduction until senescence, through going the adult stage. It also intervenes in the heritable regulation of the gene expression without any change in the nucleotide sequence, that is to say, the genotype. This allows saying that the genotype is constant and therefore does not change. However, the phenotype can be modified by the decoding of the signals from both the macro and micro cosmos. Therefore, it can be said that epigenetic is the set of chemical reactions, basically methylations and acetylations19 besides the decoding and translation of environmental signals that modify the activity of DNA without altering the genotype, but modifying the phenotype20. In short, the epigenetic changes do not alter the genes but they do alter their expression.
After the completion of the Human Genome Project in 2003, scientists from the 18 countries involved in it, discovered that the human genome is only composed of 25,000 genes. They expected to discover much more since they knew that the so-called genetic dogma encoded for the amino acid series which constitutes the tens of thousands of proteins of the human body, especially considering that about 50% of the dry weight of the cells and the human body are made of proteins21. They also realized that there is much more on the molecular basis of the cell function, the development, the aging and many diseases. The idea that scientists had just a few years ago that human beings and other organisms are fundamentally what is written in their genes since conception is changing rapidly and science is making 19
huge improvements achieving to decipher the language that encodes minor chemical changes capable of regulating the expression of many genes that depend purely on the influence of the signals from the micro- and macrocosms of the epigenome22, that means, in the purely phenotypic expression.
Epigenetic regulation can occur by changes in chromatin conformation according to its interaction with histones. This is a key level of regulation as the state in which chromatin is found, determines the time, place and manner in which a gene can be expressed or not. If chromatin is in a high condensation degree, transcription elements cannot access that DNA region and therefore, the gene is not transcribed; i.e., the gene is AMPUTATED or otherwise silenced. In contrast, if chromatin is not condensed, i.e., it is optional, the transcriptional activators can bind to the promoter regions in order the gene transcription occurs. This is one of the ways genome regulation occurs. It has been determined that there are three epigenetic regulation processes: DNA methylation, histone modification and finally the effect of small noncoding RNAs as illustrated in Fig. 3.
Until today we have been able to discern epigenetic mechanisms in a variety of physiological and pathological processes including, for example, various cancers, cardiovascular, neurological, reproductive and immune diseases.
Methylation (Fig.4) is the addition of a methyl group (-CH3) to a molecule. In development biology, methylation is the main epigenetic mechanism. Here, methylation consists in the transfer of methyl groups to some of the cytosine bases (C) of the DNA located prior and contiguously to a guanine (G). Since methylation is essential in the regulation of gene silencing, it may cause alterations in the gene transcription without causing an alteration in the DNA sequence, being one of the mechanisms responsible for the phenotypic plasticity15.
Chromatin is the set of DNA, histones, non-histone proteins and RNA found in the interphase nucleus of eukaryotic cells and constitutes the genome of those cells.
The main objective of the epigenome is to harmonize and rebalance the different vehicles of expression to achieve good health from a holistic point of view, remembering that not only environment and food will impact health, but also stress, thoughts and negative emotions, as well as the influence of the same microbiome. That expression nutritionist use “we are what we eat” should be replaced by “we are what we assimilate” because it is precisely the nutrients which, through methylation, 20
acetylation and deacetylations can modify chromatin, determining the activity of the histones at the level of their amino acids, lysine, and arginine, allowing the gene expression22.
Human beings have the opportunity to choose their destiny without any unalterable genetic determinism. This is thank to epigenetics and to the quantum energy field that receives information through signals from the micro and macro cosmos through entanglement. This allows all to be one and one to be all. Our life experience is passed from generation to generation through the epigenome. But they are the proteins that control the reading and decoding of genes23.
In quantum physics, we speak about harmonic resonance referring to the vibration between two or more waves that share the same frequency as well as the same amplitude and which is distributed in nature. In the energy quantum field, we emit thoughts and emotions which are expressed in vibrations that are mixed or entangled with other people and our thoughts recognize other vibrational frequencies that are issued by other entities and this gives a harmonious environment; however, if we emit negative thoughts in everything that surrounds us (epigenetic behavior), we create chaos and disharmony or lack of consistency among the vibratory thoughts24, 25.
So, through the epigenome, memories are passed from generation to generation, that is, what our ancestors ate, absorbed, and thought, is expressed in our epigenome as environmental signals induce its manifestation. And therefore, to nourish ourselves healthily according to our epigenetic is now a reality 26.